Searchable abstracts of presentations at key conferences in endocrinology

ea0032s16.1 | Oncogenic signals in thyroid cancer - therapeutic prospects | ECE2013

BRAFV600E and PIK3CAH1074R cooperate to promote progression of anaplastic thyroid carcinoma in the mouse

Charles Roch-Philippe , Silva Jilian , Iezza Gioia , Phillips Wayne A , McMahon Martin

Thyroid malignancies are the most common type of endocrine tumors. Of the various histological sub-types, anaplastic thyroid carcinoma (ATC) represents 2% of all cases but is responsible for most of the thyroid cancer related death.Indeed, ATC is regarded as one of the more aggressive and hard to treat forms of human cancer. Moreover, to date, there is a paucity of relevant models to study how the signature genetic abnormalities detected in ATC contribut...